RELN and hydrops fetalis: Finally, because RELN is also fundamental for the modulation of the structural and functional plastic properties of adult synapses, including the induction and maintenance of long-term potentiation (LTP) [93], it is plausible to assume that the learning and memory impairment detected in CAF-treated rats [18] could be attributed to potential alterations in the HF synapses consequent to the reduction in RELN levels.