The direct correlation between NR4A1 expression and the accessibility of the NR4A1-downstream RE defined a MALAT1/NR4A1 axis, which, according to our initial results in HeLa cells and the bioinformatic analysis of TCGA data, suggested that MALAT1 regulates NR4A1 expression through accessibility changes in the NR4A1-downstream RE in a cancer-specific manner. Here, NR4A1 is linked to cancer.