Our results indicated that, in HT-29 cells incubated with C. sorokiniana followed by rotavirus infection, the relative expression of SOCS3 and IFN-γ significantly increased as compared with that of infected cells without microalgae treatment, whereas in cells infected and treated with C. sorokiniana, the relative expression of SOCS3, STAT1, and STAT2 was significantly upregulated. The gene discussed is SOCS3; the disease is Rotavirus infection.