A combination of B. longum and C. sorokiniana was used to study its effect on the antiviral response in HT-29 by measuring the mRNA levels of IFN-γ, IL-10, SOCS3, STAT1, and STAT2 genes in cells with the combination of B. longum/C. sorokiniana in the pre- and post-infection assays with rotavirus. This evidence concerns the gene SOCS3 and infection.