The spectrum of cytokines/chemokines induced by DEN-2-infected K562 cells is not limited to IL-6, IL-8, and MCP-1; additional studies are needed to investigate whether Th1/Th2 imbalance plays a role in L-SIGN associated with DHF pathogenesis (Figure 3). The gene discussed is CXCL8; the disease is Dengue hemorrhagic fever.