Additionally, in some urothelial carcinoma patients with an FGFR3 mutation, such as FGFR3 N540K, V553M, V555L/M, or L608V, and in 50% with FGFR4-mutant hepatocellular carcinoma, resistance has been observed [97]. This evidence concerns the gene FGFR3 and urothelial carcinoma.