In the context of neurodegenerative diseases like Alzheimer’s, in vitro studies using human neuroblastoma cells (SH-SY5Y) have shown that overexpression of HSP60, alone or in combination with HSP70 and HSP90, can mitigate cytotoxicity induced by intracellular β-amyloid. This evidence concerns the gene HSPD1 and neurodegenerative disease.