HSPA5 and neuroblastoma: We also identify Grp78, Ca2+-calmodulin, Hsp90, PI3K and Akt as novel targetable participants in this mechanism, the inhibition of which enhances stress-induced killing of TrkAIII-expressing NB cells, and characterize Arf1, the MCU and ROS as non-targetable participants due to their direct involvement in DTT-induced death.