The studies reported that compounds such as 2′-hydroxyflavanone, epigallocatechin, withanolides, and oridonin inhibited breast cancer growth and proliferation by inducing apoptosis through various pathways including the mitochondrial pathway [43,47], caspase-dependent pathway [41,44,49], caspase-independent pathway [47], HSP90/HIF-1a cochaperone interaction [43,44,49], and proteasome-dependent degradation of HSP90 client proteins [44,49]. The gene discussed is HIF1A; the disease is breast cancer.