Severity and disease progression in patients with COVID-19 was shown to correlate with the expression of MyD88, i.e., a key adaptor molecule in TLR-signaling, and the expression of TLR1, TLR2, TLR4, TLR5, TLR8 and TLR9 (but not TLR3) [12]. Here, TLR4 is linked to COVID-19.