Exopolysaccharides from Lactobacillus plantarum L-14 extract inhibit adipogenesis through TLR2 and AMP-activated protein kinase (AMPK) signaling pathways, oral intake of L. plantarum L-14 extract ameliorates obesity, and obesity-associated diseases in vivo and can be used for the prevention or treatment of obesity and obesity-associated metabolic disorders [119]. The gene discussed is TLR2; the disease is obesity disorder.