The top-degree genes that were positively correlated with KRT6B were mainly associated with Staphylococcus aureus infection and the estrogen signaling pathway, and the top-degree genes that were positively correlated with SFRP2 were mainly associated with Proteoglycans in cancer, the AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, the Relaxin signaling pathway, and diabetic cardiomyopathy. The gene discussed is SFRP2; the disease is amebiasis.