After performing a canonical pathway enrichment analysis on proteins associated with severe COVID-19, we found that the top 10 significantly enriched pathways were the following: LXR/RXR activation, FXR/RXR activation, acute phase response signaling, coagulation system, intrinsic prothrombin activation pathway, iron homeostasis signaling pathway, atherosclerosis signaling, neuroprotective role of THOP1 in Alzheimer’s Disease, MSP-RON signaling in cancer cells pathway, and leukocyte extravasation signaling (Figure 3). This evidence concerns the gene F2 and COVID-19.