BCL11A and chronic kidney disease: Similarly, Ndour et al. reported no association between the rs4671393 variant in BCL11A and the risk of hyperfiltration in patients with SCA [41], while Saraf et al. found no association between the rs142740 variant in BCL11A and the risk of decreased GFR or CKD (defined as a reduction of 50% of the eGFR or need for replacement therapy) in adults with HbSS or HbS/beta0-thalassemia [30].