NPRL3 and autosomal dominant cerebellar ataxia: Furthermore, a variant in NPRL3 (rs11248850) was protective against ACR ≥ 30 mg/g in a single study of children and adults with homozygous SCA, if in combination with an α−3.7 allele (OR 0.087, p = 0.029), but it was not protective against more pronounced proteinuria or tubular proteinuria [41].