Variants in the CRYL1 (rs9315599) and VWF (rs2238104) gene were significantly associated with a higher risk of proteinuria (CRYL1: OR 3.52 (p = 7.26 × 10−7) and OR 2.91 (p = 0.00145) in the Outcome Modifying Genes in the SCD (OMG) cohort and Walk-Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sidenafil Therapy (Walk-PHaSST) cohort, respectively; VWF: OR 2.08 (p = 0.000682) and OR 2.66 (p = 0.000105), respectively). The gene discussed is CRYL1; the disease is pulmonary hypertension.