The wild-type allele (T) of the latter variant (rs1427407) was also associated with a higher odds of ACR ≥ 30 mg/g both in children and adults with HbSS or HbS/beta0-thalassemia (OR 2.3, p = 0.0077) [30,37], but significance was lost after adjusting not only for age and sex but also for diabetes, systolic blood pressure, use of hydroxyurea, treatment with an ACE inhibitor, and body mass index [30]. This evidence concerns the gene ACE and diabetes mellitus.