Ndour et al. included both children and adults with homozygous sickle cell anemia (SCA) and found no association with alpha-thalassemia, Senegal haplotype, or variants in BCL11A (rs4671393) or NPRL3 (rs11248850) [41], while Rocha et al. studied adult patients only with any SCD genotype and compared Bantu versus non-Bantu or Central African Republic (CAR) versus non-CAR haplotype. Here, NPRL3 is linked to Alpha-thalassemia.