Co-inheritance of alpha-thalassemia also led to a delayed onset of albuminuria in patients (all ages) with HbSS [21] and the presence of at least one C allele of the HMOX1 variant was associated with a decreased cumulative risk of albuminuria in children with HbSS (p = 0.028) [34]. Here, HMOX1 is linked to alpha thalassemia spectrum.