Sarcospheres formation, osteogenic and mineralization properties for bone regeneration, effective cell adhesion, migration and colonization, increased mRNA expression level of stem-related genes (OCT-4, SOX-2, NANOG), upregulated the gene expression levels (NOTC-1, HIF-1α, IL-6), signaling cascade between CSCs and tumor stem niche. Here, HIF1A is linked to neoplasm.