Promoted attachment, proliferation, osteogenic differentiation of human bone marrow stem cells, increased expression levels of osteogenic-related genes (OCN, COL1, Runx2 and ALP), bone regeneration through the BMP-2/Smad/Runx2 signaling pathway, inhibited tumor growth and triggered apoptosis and necrosis. The gene discussed is RUNX2; the disease is neoplasm.