The CXCL8-CXCR2 axis in the colon cancer microenvironment is also significant, with studies demonstrating that elevated CXCL8 levels in serum and the tumor microenvironment enhance human and murine colon cancer cell growth and support pulmonary and hepatic metastasis [44]. This evidence concerns the gene CXCL8 and malignant colon neoplasm.