CXCL12 and neoplasm: The PI3K/Akt pathway is also co-regulated by several chemokines, including CXCL12, which activates the pathway by binding to CXCR4 and enhances tumor cell resistance to apoptosis by binding to CXCR4 and enhancing the ability of tumor cells to resist apoptotic signals, thereby supporting continued tumor growth and metastasis [29,30,31,32].