GPX3 and Hyperglycemia: For example, hyperglycemia-induced alterations in miRNA expressions influence the level of molecules essential in antioxidant signaling such as Sirtuin-1 (SIRT1), forkhead box class O (FOXOs), Kelch-like ECH-associated protein 1/nuclear factor-erythroid 2 p45-related factor 2 (Keap1/Nrf2), SOD1/2, GPx-3, and CAT.