Another LOX-derived oxylipin named LTC4 was found to induce the tumor suppressor 15-PGDH (15-hydroxyprostaglandin dehydrogenase), which leads to the downregulation of glioma-associated oncogene (GLI1) expression in a PKA (protein kinase A)-dependent manner, contributing to differentiation in CRC cells (Figure 3) [56]. The gene discussed is HPGD; the disease is colorectal carcinoma.