Accordingly, in PAECs from IPAH patients (Figure 7C) and in BMPR2-silenced PAECs (Figure 7D), DLL4 not only induced PPARG transcription, but also increased mRNA expression of several PPARγ target genes (FABP4, CYP1A1, PGK1 and HK1). The gene discussed is BMPR2; the disease is idiopathic pulmonary arterial hypertension.