The reduction in IL-6, TNF-α, INF-γ, IL-12p70, MCP-1, IL-17a, and IL-10 lung concentrations in this ARDS model by lefamulin are consistent with those observed in the LPS-induced lung neutrophilia mouse model where single SC doses of 35, 70, and 140 mg/kg lefamulin resulted in reduced cytokine and chemokine concentrations (TNF-α, IL-6, IL-1β, and GM-CSF, CXCL-1, CXCL-2, CCL-2, MMP-9) in lung tissue and reduced infiltration of the lung by inflammatory monocytes and neutrophils when compared to the vehicle control [39]. The gene discussed is IL1B; the disease is acute respiratory distress syndrome.