Also in line with histopathology are the concentrations of IL-10, which is known as an anti-inflammatory mediator capable of down-regulating acute lung inflammation, but also with an ambiguous role, since elevated plasma levels have been correlated with the accelerated mortality of lung contusion and pneumonia in mice [61] and higher mortality of ARDS and CAP patients [62,63]. Here, IL10 is linked to acute respiratory distress syndrome.