Their results have confirmed predominant Cx50 expression in the adrenal medulla and Cx43 expression in the adrenal cortex, while Cx43 was present and Cx50 was low in malignant pheochromocytomas in comparison to normal adrenal medulla and benign pheochromocytomas [27]. Here, GJA8 is linked to malignant adrenal gland pheochromocytoma.