In the presence of AC-EO, cell viability is dose-dependently decreased through the downregulation of p-ERK expression and the upregulation of apoptotic factors such as Bax and caspases-3 and -9 in human epidermoid carcinoma A431, human SK-MEL-28 melanoma, and murine B16F10 melanoma [133]. Here, CASP3 is linked to melanoma.