Furthermore, Gigliotti et al. investigated the effect of CN-CPT in an orthotopic model of ATC obtained by the injection of Cal-62 cells into the thyroid lobe of female NSG mice, showing that CN-CPT significantly decreased the growth velocity, the development of the metastasis, and the tumor microvessel density (assessed by CD31 staining) of orthotopic ATC xenografts, without apparent toxicity [27]. Here, PECAM1 is linked to neoplasm.