CD4 and neoplasm: The paradoxical effect of tumor-intrinsic EZH2 knockout on infiltrated neutrophils (decrease) as well as CD4+ and CD8+ T cells (increase) was even more striking when expressed as ratios, revealing a >20-fold decrease in the neutrophil:CD8+ T-cell ratio in EZH2 KO vs. WT and EZH2 OE tumors (Figure 5B).