STAT3 and neoplasm: Upregulated EZH2 contributes to tumor development, progression, and metastasis via multiple downstream pathways, including but not limited to the modulation of stimulator of interferon genes (STINGs) [13], transforming growth factor β (TGF β) [14], signal transducer and activator of transcription 3 (STAT3) [15], and Wnt [16] signaling.