BRAF and colorectal carcinoma: These two cell lines were chosen because they are CRC cell lines with distinct cellular (grades of differentiation [32] and migratory and metastatic potential [33,34]) and molecular phenotypic (Caco-2 cells are BRAF- and PI3KCA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α)-wild type, whereas HT-29 cells are BRAF- and PI3KCA-mutant) characteristics.