NLRP3 and idiopathic dilated cardiomyopathy: In patients with idiopathic dilated cardiomyopathy, levels of circulating NLRP3, ASC, caspase-1, and IL-1β were significantly elevated compared to those in healthy controls, with higher NLRP3 mRNA levels correlating with reduced LV ejection fraction, and elevated natriuretic peptides and monocyte count [43].