FOSL1 has been found to exhibit high expression levels and demonstrated an oncogene in numerous tumor types including thyroid tumors, gastric cancer (GC) [11], breast cancer, hepatocellular carcinoma (HCC) [12], head and neck squamous cell carcinoma (HNSCC) [13], nephroblastoma, and laryngeal squamous cell carcinoma [10,14]. This evidence concerns the gene FOSL1 and head and neck squamous cell carcinoma.