Of note, among the 6 H-SIL cases, only 2/6 cases showed the mixed p16 pattern, while in the remaining 4/6 H-SIL cases the w/f p16 pattern persisted, although they clearly showed morphological characteristics of H- SIL and high proliferation rate, as evidenced by Ki67 score 3+. This evidence concerns the gene CDKN2A and squamous cell intraepithelial neoplasia.