TNF and neurodegenerative disease: An increase in proinflammatory cytokines, such as tumor necrosis factor-alpha (TNFα) and interleukin-1b (IL-1b), and caustic molecules released during inflammation, such as nitric oxide (NO) and myeloperoxidase (MPO), have been associated with a worse prognosis across multiple neurodegenerative diseases [2,6].