The model relies on the expression of TLR7 [61] and has been used to determine the role of other TLRs like TLR2 [62], TLR4 [63], and TLR9 [63,64], in addition to induction factors like BAFF [65] and tonicity-responsive enhancer-binding protein (TonEBP) [66] and signaling molecules and sensors like IRF7 [67], cGAS-STING pathway [68], and IRAK4 [69] in murine lupus. Here, TLR4 is linked to systemic lupus erythematosus.