Interestingly, in relation to SLE, Lee et al. (2018) showed that the binding of TLR10 to dsRNA activated the MyD88 signaling pathway and suppression of IRF7-dependent type I IFN expression as well as inhibition of TLR3 signaling through sequestering dsRNA from this receptor [107]. The gene discussed is TLR3; the disease is systemic lupus erythematosus.