Several anti-nuclear autoantibodies (ANAs), such as anti-double-stranded DNA (dsDNA), anti-nucleosome (nuc), anti-Sm, anti-small nuclear riboprotein (snRNP), anti-Sjogrens syndrome antigen A (SSA/Ro), anti-Sjogrens syndrome antigen B (SSB/La), anti-phospholipid (PL), and anti-C1q antibodies have been implicated in SLE, but anti-dsDNA and anti-Sm are the only antibodies that are considered specific for SLE [1]. The gene discussed is LSM2; the disease is systemic lupus erythematosus.