Other nucleic acid sensors such as cytosolic dsRNA sensors, including melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-1), and DNA sensors such as cyclic GMP-AMP synthase (cGAS), interferon-gamma inducible 16 (IFI16), absent in melanoma 2 (AIM2), and DNA-dependent activator of IRFs (DAI) may also be involved in SLE. The gene discussed is ZBP1; the disease is systemic lupus erythematosus.