Surprisingly, the VD3-GNP treatment is found to downregulate ETV7, the PI3K/mTOR/AKT cascade, along with the HIPPO pathway’s key proteins YAP and TAZ, which indicates its importance in controlling breast cancer aggressiveness (Figure 8 and Figure 9) [35,36,39,40,41,42,43]. This evidence concerns the gene AKT1 and breast carcinoma.