The PPFP has been described as an inhibitor of PPARγ activity or a transcription factor with proto-oncogene activity [16]; however, in mice, pioglitazone reportedly binds to the PPFP and induces it to behave like PPARγ, resulting in loss of malignancy as thyroid cancer cells differentiate into adipocyte-like cells [9,10,13]. The gene discussed is PPARG; the disease is thyroid cancer.