This pattern of changes was confirmed in a study by Zhang et al. [154] in which it was shown that both natural and artificial infection of domestic rabbits with GI.1–RHDV results in changes in its presentation by MHC antigens to T lymphocytes, while infection with GI.2–RHDV2/b of wild-type rabbits results in an increased expression of MHC class I genes [32,103]. The gene discussed is HLA-C; the disease is infection.