Diagnostic testing established 91% sensitivity and 85% diagnostic accuracy of the C-OCE with a threshold of stiffness above 803 kPa for detecting the presence of one of KRAS, NRAS, or BRAF driver mutations in CRC, and 90% sensitivity and 89% diagnostic accuracy of the C-OCE with a threshold of stiffness above 850 kPa for detecting the presence of KRAS driver mutation in CRC. The gene discussed is NRAS; the disease is colorectal carcinoma.