We present a comprehensive study of individual morphological patterns of CRC cells using three methods—C-OCE, molecular analysis, and histology—where histological examination plays a connecting role between changes in stiffness values determined by C-OCE and the presence/absence of KRAS, NRAS, BRAF genes driver mutations and microsatellite status performed by molecular analysis. The gene discussed is KRAS; the disease is colorectal carcinoma.