Some papers demonstrate the connection between the identification of poorly differentiated tumor clusters (solid patterns inherent in high-grade CRC) and KRAS mutations [22]/BRAF mutations [23]/MSS [24]; the involvement of KRAS mutations in the formation of solid CRC patterns has also been suggested [25], as well as the ability to predict MSI cases when evaluating histological images of CRC using machine learning technologies [26]. The gene discussed is BRAF; the disease is colorectal carcinoma.