CTNNB1 and osteoarthritis: Other molecules of the first group are as follows: neuropeptide Y (NPY) [14,34], a fundamental regulator of bone homeostasis and osteoblasts, with a role in the response to mechanical stimuli and in osteoarthritis [14,34]; the members of the WNT/β-catenin (CTNNB1) signaling pathway, of crucial importance in proliferation, regeneration, embryonic development, and morphogenesis of various tissues including the musculoskeletal ones [14,35].