Activation of α7nAchRs by nicotine contributes to CRC cell proliferation via MAPK/ERK signaling [156,158], inhibition of apoptosis [159], stimulation of CRC cell migration by fibronectin, MMP-1, -2, and -9 induction [158,160], and angiogenesis [157]. This evidence concerns the gene CHRNA7 and colorectal carcinoma.