Even though α7nAChR agonism with AR-R17779 and GSK1345038A was not protective in a murine colitis model [177], increased central ACh via treatment with a cholinesterase inhibitor attenuated colitis and reduced the risk of colitis-associated cancer due to activation of the cholinergic anti-inflammatory pathway via α7nAchR [178]. Here, CHRNA7 is linked to cancer.