In light of the recognized role of the Akt/mTOR network in acne, there is an emerging interest in developing novel therapeutic agents targeting the mTORC1- and FoxO1-dependent signaling pathways to mitigate mTORC1/SREBP1-mediated sebum production, which plays a significant role in the pathology of acne [334]. This evidence concerns the gene SREBF1 and acne.