Cardiomyopathy that evolves to congestive refractory heart failure is characteristic of dystrophinopathies (DMD, BMD, and X-linked DilatedCardioMyopathy (XL-DCM), females with dystrophinopathy), some forms of limb-girdle muscular dystrophies (LGMDR5, R6, R9, R13, and R14) [3], and congenital muscular dystrophies. Here, SGCG is linked to neuromuscular disease caused by qualitative or quantitative defects of dystrophin.