This report focuses on the relationship between the polymorphisms rs1800797, rs1800796, and rs1800795 in the promoter of the IL6 gene encoding for interleukin-6 and polymorphism rs2228145 of the IL6R gene encoding for the alpha subunit of the IL-6 receptor with the predisposition to keloid scar formation in Polish individuals. This evidence concerns the gene IL6 and keloid.