It is associated with cardiovascular and cerebrovascular events in patients undergoing percutaneous coronary surgery [24,25] and is even related to inflammatory diseases such as sleep apnea [26]; moreover, in patients with rheumatoid arthritis (the soluble portion of LOX-1 has been identified in synovial fluid) [27] and obesity [28]. The gene discussed is OLR1; the disease is obesity due to melanocortin 4 receptor deficiency.