The signaling pathway is turned on when the proprotein convertase subtilisin/kexin type 9 (PCSK9), which is a plasma protein, regulates the expression of the toll-like receptor; it has been studied that it is linked with some inflammatory mediator scavenger receptors, such as LOX-1, exacerbating the inflammatory response, thus showing an inflammatory response in atherosclerosis and, with it, the expression of these cytokines [49]. The gene discussed is OLR1; the disease is atherosclerosis.