There is a relationship between dyslipidemia and the activation of the renin–angiotensin system that triggers atherogenesis; the increasing expression of the low-density lipoprotein receptor similar to lectin LOX-1 in knockout mice for Apo-E fed a high-cholesterol diet shows extensive atherosclerosis, as determined by Sudan IV staining. The gene discussed is OLR1; the disease is atherosclerosis.