Although numerous authors agree that high intratumoral EZH2 expression indicates poor prognosis in regard to HNSCC (Mochizuki et al. [34]; Chang et al. [35]; Wu et al. [36]), some controversy remains regarding which tumor characteristics (e.g., lymph node metastasis (Nienstedt et al. [21])) are the most significantly affected by the actions of EZH2. Here, EZH2 is linked to head and neck squamous cell carcinoma.