For example, KV1.3 channels are considered as therapeutic targets of autoimmune diseases like multiple sclerosis [28,29], while KCa3.1 is implicated in various autoimmune diseases and inflammation developments, including rheumatoid arthritis, asthma, T-cell mediated colitis, and vascular inflammation [30,31,32,33]. This evidence concerns the gene KCNA3 and rheumatoid arthritis.