Recent studies have speculated that prostate enlargement may result from the accumulation of cells as a result of epithelial proliferation and the EMT process, as suggested by the evidence of a lower expression of the epithelial marker E-cadherin and a higher expression of the mesenchymal marker vimentin in BPH tissues, providing novel insight into the origin of stromal cells [52,53,54]. Here, CDH1 is linked to benign prostatic hyperplasia.