Women with SLE planning pregnancy should undergo testing for the presence of anti-Ro/SSA, anti-La/SSB, and antiphospholipid antibodies (e.g., anticardiolipin IgG, and IgM, b2-glycoprotein-I IgG, and IgM, and lupus anticoagulant (LAC). Here, CD40LG is linked to systemic lupus erythematosus.