DAMPs (damage-associated molecular patterns), such as LDL, cholesterol crystals, calcium pyrophosphate crystals, uric acid crystals, hyperglycemia, disrupted blood flow, and hypoxia [23], activate the NLRP3 inflammasome, which produces interleukin-1β (IL-1β) via caspase-1-mediated cleavage of pro-IL-1β. Here, IL1B is linked to Hyperglycemia.