TF and steatosis: It then compiles a detailed exploration of the mechanisms underpinning drug-induced steatosis and liver damage, including mitochondrial dysfunction, lipid metabolism aberrations, and alternative pathways like increased de novo lipogenesis (DNL) and compromised lipid export mechanisms via very low-density lipoprotein (VLDL), along with the involvement of nuclear receptors (NRs) and transcription factors (TF).