NR4A2 and early-onset autosomal dominant Alzheimer disease: Given the functions of NR4A2 in the maintenance and survival of dopaminergic neurons in the midbrain [41], as well as in the hippocampus and cortex [42], a dysregulation of its activity was proposed to play a role in the onset or progression of neurodegenerative diseases such as Parkinson’s or Alzheimer’s disease.