Among the 77 AML patients with KMT2A gene rearrangements, the most frequent abnormality was KMT2A::MLLT3 (31/77; 40.3%), followed by KMT2A::MLLT4 (17/77; 22.1%), KMT2A::MLLT10 (12/77; 15.6%), and KMT2A::ELL (4/77; 5.2%). The gene discussed is AFDN; the disease is acute myeloid leukemia.