To characterize DNA-binding proteins and passengers proteins identified in blood-circulating NPCs, a bioinformatics analysis was performed using InterPro and InterProScan databases versions 5.15-58 and 5.15-54,24,25, allowing us to identify the GO categories for NPC proteins from HFs (Supplementary Table S3) and BCPs (Supplementary Table S4) (isoforms not shown). Here, NPC1 is linked to Hand-foot syndrome.