In this population, 1182 subjects with nucleotide alterations in coding regions or in regulatory regions (splicing sites) of the GLA gene were found: among these, 827 had a mutation responsible for the classic variant or late-onset variants of Fabry disease, 355 subjects had a mutation considered to be a genetic variant of uncertain significance (GVUS), and the remainder had no variations in the coding or regulatory regions of the GLA gene. The gene discussed is GLA; the disease is Fabry disease.