Specifically, MTX-211 demonstrated the significant inhibition of AKT at both threonine 308 (pT308 AKT) and serine 473 (pS473 AKT), and EGFR phosphorylation in S1 cancer cells, exhibiting IC50 values of 2.72 ± 1.23, 1.50 ± 0.61, and 6.64 ± 1.27 μM, respectively (Figure 3, open circles). Here, AKT1 is linked to cancer.